Hidehiko Nakagawa, Ph.D., Professor
Mitsuyasu Kawaguchi, Ph.D., Associate Professor
Yuhei Ohta, Ph.D., Research Associate

• Molecular design, synthesis, and evaluation of biologically functional and useful compounds
• ハントカジノ ボーナスコード methods for exploration and analysis for bioactive substances like medical leads based on chemical approach
• Bioorganic chemistry for reactive oxygen species and nitric oxide
• ハントカジノ ボーナスコード compounds for controlling cellular properties based on photochemistry and organic chemistry

Oriented toward the ハントカジノ ボーナスコード medical and diagnostic drugs, the studies in medicinal chemistry and chemical biology are conducted. To find attractive lead compounds and to tune them up to novel and useful biofuctional chemicals, we practice comprehensive studies of computational molecular design, synthetic reactions, biological evaluation, and action mechanisms of biofunctional molecules on the basis of organic chemistry. Our research interest includes the ハントカジノ ボーナスコード histone deacetylase inhibitors, photoinduced nitric oxide donors, adipocyte proliferation regulating compounds, DNA methylation regulating compounds, oxidative stress regulating compounds, and so on.

The followings are brief introductions of our biofunctional compounds.

(1) Novel chemial fluorescent probes for deaceylase/deacylase activity to explore potential inhibitors: The probe compounds were designed ハントカジノ ボーナスコードynthesized based on the FRET mechanism, and on the finding of deacylation activity of the enzymes for the non-natural acyl moiety containing aromatic quencher group. The synthesized compounds showed potent turn-on fluorescence response for SIRT enzymatic acitvity ハントカジノ ボーナスコードome of the probes were also fonund to be applicable for the detection of SIRT activity in living cells. These compounds are expected to become novel tools for exploring new drug candidates.

Prof. Hidehiko Nakagawa, Ph.D.
deco@phar.nagoya-cu.ac.jp