ハントカジノ 登録方法
ハントカジノ 登録方法: Discovery of growth cone in migrating neurons involved in promoting neuronal migration and regeneration in the brain after injury
Summary Text
The structure and functions of the tip of migrating neurons remain elusive. Here, a research group led by Kazunobu Sawamoto, Professor at Nagoya City University and National Institute for Physiological Sciences, and by Chikako Nakajima and Masato Sawada, staff scientists in his laboratory, has elucidated that the PTPσ-expressing ハントカジノ 登録方法 senses the extracellular matrix and drives neuronal migration in the injured brain, leading to functional recovery.
Full Text
The structure and functions of the tip of migrating neurons remain elusive. Here, a research group led by Kazunobu Sawamoto, Professor at Nagoya City University and National Institute for Physiological Sciences, and by Chikako Nakajima and Masato Sawada, staff scientists in his laboratory, has found that the PTPσ-expressing ハントカジノ 登録方法 senses the extracellular matrix and drives neuronal migration in the injured brain, leading to functional recovery.
Neural stem cells are present in the postnatal mammalian brain and produce new neurons. New neurons migrate toward injured sites, and promoting neuronal migration results in functional recovery after brain injury. Nevertheless, there is an inhibitory effect on neuronal migration in the injured sites, the mechanisms of which need to be elucidated in order to improve recruitment of new neurons in the injured sites and thus to enhance the recovery after brain injury. The migrating neurons possess an axonal ハントカジノ 登録方法-like structure at their tip, but the role of this structure in neuronal migration has not been fully understood.
Sawamoto’s group focused on elucidating the function of the ハントカジノ 登録方法-like structure of migrating neurons of the mouse brain. The researchers used super-resolution microscopy to study the cytoskeletal dynamics and molecular features of the neuronal tip. They showed that the tip structure shares important functions with axonal ハントカジノ 登録方法s. In short, the ハントカジノ 登録方法 of cultured migrating neurons is responsive to external signals through tyrosine phosphatase receptor type sigma (PTPσ) to guide the directionality of migration and initiate the movement of their cell body. The ハントカジノ 登録方法 responds to chondroitin sulfate (CS) through PTPσ and collapses, resulting in inhibition of neuronal migration. In the presence of CS, the ハントカジノ 登録方法s can revert to their extended morphology when they interact with heparan sulfate (HS), thus re-enabling neuronal migration.
“To investigate whether the effect of HS in reversing the inhibitory effect of CS can promote neuronal migration ハントカジノ 登録方法 injured brain, it was necessary to apply HS-containing biomaterial to the CS-rich injured brain,” Sawamoto said.
Next, they employed HS-containing gelatin-fiber nonwoven fabric, a biomaterial that provides structural scaffolds for cells such as migrating neurons. They showed that the applied HS-containing fibers promoted extension of ハントカジノ 登録方法s and neuronal migration in the injured brain. Furthermore, implantation of the HS-enriched gelatin fabric promoted the regeneration of mature neurons and restored neurological functions. These results suggest that elucidating the molecular mechanisms of ハントカジノ 登録方法-mediated interaction with the local extracellular environment may enable the development of new regeneration technologies based on the promotion of neuronal migration.
Recent studies by other groups have shown that aging alters the physical properties of brain extracellular matrix, including CSPG.
“Given that the ハントカジノ 登録方法 of migrating neurons serves as a primer for neuronal migration under inhibitory extracellular conditions, it is necessary to further investigate whether the ハントカジノ 登録方法-mediated treatment to recruit new neurons from the endogenous source to the damaged sites is also applicable to aged brains,” Nakajima commented.
The full findings of the study are published in Nature Communications.
Article title: Identification of the ハントカジノ 登録方法 as a probe and driver of neuronal migration in the injured brain. DOI: 10.1038/s41467-024-45825-8
In addition to Kazunobu Sawamoto, Chikako Nakajima, and Masato Sawada, co-authors of this research article include researchers from Nagoya City University, National Institute for Physiological Sciences, Niigata University, Kyoto University, Doshisha University, Jichi Medical University, The Japan Wool Textile Co., Ltd., Nikke Medical Co., Ltd., Toray Research Center, Inc., New York University, Friedrich Schiller University Jena, University of Valencia, and University of Pennsylvania.
Summary Text
The structure and functions of the tip of migrating neurons remain elusive. Here, a research group led by Kazunobu Sawamoto, Professor at Nagoya City University and National Institute for Physiological Sciences, and by Chikako Nakajima and Masato Sawada, staff scientists in his laboratory, has elucidated that the PTPσ-expressing ハントカジノ 登録方法 senses the extracellular matrix and drives neuronal migration in the injured brain, leading to functional recovery.
Full Text
The structure and functions of the tip of migrating neurons remain elusive. Here, a research group led by Kazunobu Sawamoto, Professor at Nagoya City University and National Institute for Physiological Sciences, and by Chikako Nakajima and Masato Sawada, staff scientists in his laboratory, has found that the PTPσ-expressing ハントカジノ 登録方法 senses the extracellular matrix and drives neuronal migration in the injured brain, leading to functional recovery.
Neural stem cells are present in the postnatal mammalian brain and produce new neurons. New neurons migrate toward injured sites, and promoting neuronal migration results in functional recovery after brain injury. Nevertheless, there is an inhibitory effect on neuronal migration in the injured sites, the mechanisms of which need to be elucidated in order to improve recruitment of new neurons in the injured sites and thus to enhance the recovery after brain injury. The migrating neurons possess an axonal ハントカジノ 登録方法-like structure at their tip, but the role of this structure in neuronal migration has not been fully understood.
Sawamoto’s group focused on elucidating the function of the ハントカジノ 登録方法-like structure of migrating neurons of the mouse brain. The researchers used super-resolution microscopy to study the cytoskeletal dynamics and molecular features of the neuronal tip. They showed that the tip structure shares important functions with axonal ハントカジノ 登録方法s. In short, the ハントカジノ 登録方法 of cultured migrating neurons is responsive to external signals through tyrosine phosphatase receptor type sigma (PTPσ) to guide the directionality of migration and initiate the movement of their cell body. The ハントカジノ 登録方法 responds to chondroitin sulfate (CS) through PTPσ and collapses, resulting in inhibition of neuronal migration. In the presence of CS, the ハントカジノ 登録方法s can revert to their extended morphology when they interact with heparan sulfate (HS), thus re-enabling neuronal migration.
“To investigate whether the effect of HS in reversing the inhibitory effect of CS can promote neuronal migration ハントカジノ 登録方法 injured brain, it was necessary to apply HS-containing biomaterial to the CS-rich injured brain,” Sawamoto said.
Next, they employed HS-containing gelatin-fiber nonwoven fabric, a biomaterial that provides structural scaffolds for cells such as migrating neurons. They showed that the applied HS-containing fibers promoted extension of ハントカジノ 登録方法s and neuronal migration in the injured brain. Furthermore, implantation of the HS-enriched gelatin fabric promoted the regeneration of mature neurons and restored neurological functions. These results suggest that elucidating the molecular mechanisms of ハントカジノ 登録方法-mediated interaction with the local extracellular environment may enable the development of new regeneration technologies based on the promotion of neuronal migration.
Recent studies by other groups have shown that aging alters the physical properties of brain extracellular matrix, including CSPG.
“Given that the ハントカジノ 登録方法 of migrating neurons serves as a primer for neuronal migration under inhibitory extracellular conditions, it is necessary to further investigate whether the ハントカジノ 登録方法-mediated treatment to recruit new neurons from the endogenous source to the damaged sites is also applicable to aged brains,” Nakajima commented.
The full findings of the study are published in Nature Communications.
Article title: Identification of the ハントカジノ 登録方法 as a probe and driver of neuronal migration in the injured brain. DOI: 10.1038/s41467-024-45825-8
In addition to Kazunobu Sawamoto, Chikako Nakajima, and Masato Sawada, co-authors of this research article include researchers from Nagoya City University, National Institute for Physiological Sciences, Niigata University, Kyoto University, Doshisha University, Jichi Medical University, The Japan Wool Textile Co., Ltd., Nikke Medical Co., Ltd., Toray Research Center, Inc., New York University, Friedrich Schiller University Jena, University of Valencia, and University of Pennsylvania.
Neuronal ハントカジノ 登録方法
Collective time-lapse images of a migrating neuron (left) and an elongating axon (right) from super-resolution microscopy. ハントカジノ 登録方法s at the tips of the neurons are extended while the cell body migrates and the axon elongates.
Reference
DOI:10.1038/s41467-024-45825-8
Author
Kazunobu Sawamoto
DOI:10.1038/s41467-024-45825-8
Author
Kazunobu Sawamoto