UV Disinfection ハントカジノ 銀行振込e Treatment Management of SARS-CoV-2 Omicron Variants
Summary Text
UV radiation withハントカジノ 銀行振込e wavelength range of 200–300 nm effectively kills pathogenic microorganisms, although it poses a risk of protein and DNA damage in humans. ハントカジノ 銀行振込is study, researchers from Japan, investigated the effectiveness of different UV wavelengths in inactivating two variants of SARS-CoV-2. The study revealed that the 220 nm UV light, considered safe for humans, had comparable inactivation efficacy to the hazardous 260 nm light, for both the variants.
Full Text
The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new variants has created a need for effective disinfection technologies to protect against harmful pathogens. While vaccines offer some protection, their effectiveness against future variants is uncertain. Therefore, additional strategies are important during the pre-vaccine stage.
UV irradiation has lately emerged as a safe, effective, and convenient strategy to inactivate and eliminate disease-causing micro-organisms. The wavelength range of 200-235 nm, often referred to as far-UVC, is being increasingly investigated as a novel disinfection wavelength. Even though it has been shown to be harmless to mammalian cells due to ハントカジノ 銀行振込trong absorption effect of ハントカジノ 銀行振込tratum corneum layer, ハントカジノ 銀行振込afety of UV irradiation on mammalian cells is not well-established, and there are concerns that high levels of far-UVC light can cause damage to ハントカジノ 銀行振込kin cells. Further, available study data has significant inconsistencies that might be caused by the differences in both ハントカジノ 銀行振込trains of SARS-CoV-2 and experimental conditions such as ハントカジノ 銀行振込pectrum of the light sources. To address these issues, Prof. Takahiro Matsumoto from the Graduate School of Design and Architecture, Nagoya City University, along with his team, conducted systematic experiments using varying UV wavelengths without variance in other experimental conditions. The dedicated team of scientists included Prof. Makoto Tomita from Shizuoka University, Prof. Tadao Hasegawa from Nagoya City University, and Prof. Yasuhito Tanaka from Kumamoto University, among others. Their study was published online on 15th June, 2023 in Scientific Reports.
To explore the interaction of UV rays with two omicron variants of coronavirus, the team conducted a series of experiments. First, they isolated omicron BA.2 and BA.5 variants of SARS-CoV-2 from the infected cells (VeroE6/TMPRSS2). Next, they subjected the isolated omicron BA.2 and BA.5 variants to ハントカジノ 銀行振込rradiation across a range of wavelengths, specifically ranging from 200 to 260 nm. For each wavelength, varying doses of ハントカジノ 銀行振込rradiation, ranging from 0 to 18 mJ/cm2, were applied. The inactivation rate constant–which quantifies effectiveness of the treatment—was calculated by using two methods, TCID50 (tissue culture infectious dose) and qPCR (quantitative polymerase chain reaction).
ハントカジノ 銀行振込tudy showed that both omicron BA.2 and BA.5 variants have almost identical UV inactivation properties. Although the inactivation rates were highest at 260 nm, the rates obtained with 220 nm light were similar to those obtained with the former. The findings highlight the potential of far-UVC light as a safe germicidal option. "The comparable inactivation efficacy between 220 nm and 260 nm light suggests that far-UVC light could be a promising and safe approach to mitigate airborne virus transmission,” concludes Prof. Matsumoto.
Furthermore, it was found that the ハントカジノ 銀行振込nactivation rate constants obtained in a liquid suspension were approximately 10 times lower than those previously obtained in an aerosol, suggesting the potential role of the Mie scattering effect in enhancing ハントカジノ 銀行振込rradiance within aerosol droplets.
Additionally, the bacteria E. coli was used as a reference point to compare and understand the differences in inactivation and genome damage when compared to the SARS-CoV-2 omicron variants. The study found that, above 240 nm, both SARS-CoV-2 and E. coli exhibit similar sensitivities to UV light, indicating UV-induced inactivation primarily targets genes (DNA or RNA). However, below 240 nm, significant differences were observed, which can be attributed to the difference ハントカジノ 銀行振込ickness of the protein layer covering DNA or RNA. Also, the spectral sensitivities obtained through TCID50 assays and qPCR assays indicated correlation between the two methods.
This study provides valuable insights into the UV susceptibility of SARS-CoV-2 omicron variants. The observed similarities in inactivation efficacy between 220 nm and 260 nm light, in combination with aerosols, suggest the potential use of far-UVC light for preventing airborne virus transmission in a safe and practical manner. It is expected that, the results obtained here will pave way toward safe ultraviolet sterilization technologies ハントカジノ 銀行振込e near future.
UV radiation withハントカジノ 銀行振込e wavelength range of 200–300 nm effectively kills pathogenic microorganisms, although it poses a risk of protein and DNA damage in humans. ハントカジノ 銀行振込is study, researchers from Japan, investigated the effectiveness of different UV wavelengths in inactivating two variants of SARS-CoV-2. The study revealed that the 220 nm UV light, considered safe for humans, had comparable inactivation efficacy to the hazardous 260 nm light, for both the variants.
Full Text
The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new variants has created a need for effective disinfection technologies to protect against harmful pathogens. While vaccines offer some protection, their effectiveness against future variants is uncertain. Therefore, additional strategies are important during the pre-vaccine stage.
UV irradiation has lately emerged as a safe, effective, and convenient strategy to inactivate and eliminate disease-causing micro-organisms. The wavelength range of 200-235 nm, often referred to as far-UVC, is being increasingly investigated as a novel disinfection wavelength. Even though it has been shown to be harmless to mammalian cells due to ハントカジノ 銀行振込trong absorption effect of ハントカジノ 銀行振込tratum corneum layer, ハントカジノ 銀行振込afety of UV irradiation on mammalian cells is not well-established, and there are concerns that high levels of far-UVC light can cause damage to ハントカジノ 銀行振込kin cells. Further, available study data has significant inconsistencies that might be caused by the differences in both ハントカジノ 銀行振込trains of SARS-CoV-2 and experimental conditions such as ハントカジノ 銀行振込pectrum of the light sources. To address these issues, Prof. Takahiro Matsumoto from the Graduate School of Design and Architecture, Nagoya City University, along with his team, conducted systematic experiments using varying UV wavelengths without variance in other experimental conditions. The dedicated team of scientists included Prof. Makoto Tomita from Shizuoka University, Prof. Tadao Hasegawa from Nagoya City University, and Prof. Yasuhito Tanaka from Kumamoto University, among others. Their study was published online on 15th June, 2023 in Scientific Reports.
To explore the interaction of UV rays with two omicron variants of coronavirus, the team conducted a series of experiments. First, they isolated omicron BA.2 and BA.5 variants of SARS-CoV-2 from the infected cells (VeroE6/TMPRSS2). Next, they subjected the isolated omicron BA.2 and BA.5 variants to ハントカジノ 銀行振込rradiation across a range of wavelengths, specifically ranging from 200 to 260 nm. For each wavelength, varying doses of ハントカジノ 銀行振込rradiation, ranging from 0 to 18 mJ/cm2, were applied. The inactivation rate constant–which quantifies effectiveness of the treatment—was calculated by using two methods, TCID50 (tissue culture infectious dose) and qPCR (quantitative polymerase chain reaction).
ハントカジノ 銀行振込tudy showed that both omicron BA.2 and BA.5 variants have almost identical UV inactivation properties. Although the inactivation rates were highest at 260 nm, the rates obtained with 220 nm light were similar to those obtained with the former. The findings highlight the potential of far-UVC light as a safe germicidal option. "The comparable inactivation efficacy between 220 nm and 260 nm light suggests that far-UVC light could be a promising and safe approach to mitigate airborne virus transmission,” concludes Prof. Matsumoto.
Furthermore, it was found that the ハントカジノ 銀行振込nactivation rate constants obtained in a liquid suspension were approximately 10 times lower than those previously obtained in an aerosol, suggesting the potential role of the Mie scattering effect in enhancing ハントカジノ 銀行振込rradiance within aerosol droplets.
Additionally, the bacteria E. coli was used as a reference point to compare and understand the differences in inactivation and genome damage when compared to the SARS-CoV-2 omicron variants. The study found that, above 240 nm, both SARS-CoV-2 and E. coli exhibit similar sensitivities to UV light, indicating UV-induced inactivation primarily targets genes (DNA or RNA). However, below 240 nm, significant differences were observed, which can be attributed to the difference ハントカジノ 銀行振込ickness of the protein layer covering DNA or RNA. Also, the spectral sensitivities obtained through TCID50 assays and qPCR assays indicated correlation between the two methods.
This study provides valuable insights into the UV susceptibility of SARS-CoV-2 omicron variants. The observed similarities in inactivation efficacy between 220 nm and 260 nm light, in combination with aerosols, suggest the potential use of far-UVC light for preventing airborne virus transmission in a safe and practical manner. It is expected that, the results obtained here will pave way toward safe ultraviolet sterilization technologies ハントカジノ 銀行振込e near future.
Inactivation of SARS-CoV-2 BA.2 and BA.5 at 220 nm and 260 nm as a function of UV dose (mJ/cm2)
Solid circles show the viral infectivity obtained by TCID50 assay, and solid squares show the reduction in RNA amplification determined by qPCR, where the relative ratio to those of unexposed controls was used. The inactivation efficacy of (a) 220 nm light, which is considered safe for the human body, was approximately ハントカジノ 銀行振込ame as that of health hazardous (b) 260 nm light for both BA.2 (dark dots) and BA.5 (light dots).