ハントカジノ 出金時間elix of life: New study shows how "our" RNA stably binds to artificial nucleic acids
December 9,2020
As medical research progresses, traditional treatment protocols are being rapidly exhausted. New approaches to treat diseases that do not respond to conventional drugs are the need of ハントカジノ 出金時間our. In search for these approaches, science has turned to a wide range of potential answers, including artificial nucleic acids. Artificial or xeno nucleic acids are similar to naturally occurring nucleic acids (think DNA and RNA) -- but are produced entirely in the laboratory.
Xeno ハントカジノ 出金時間s are essential for the development of ハントカジノ 出金時間-based drugs. To be effective, they need to be able to stably bind to natural RNA (a cellular single-stranded version of the DNA, which is essential for all body processes). However, it is unclear how, if at all, RNA hybridizes with these xeno ハントカジノ 出金時間s. A new study by researchers from Japan sheds light on this mechanism, opening doors to the development of potentially revolutionary ハントカジノ 出金時間-based drugs.
In their experimental study published in Communications Chemistry, the team of the researchers was able to determine three-dimensional structures of RNA hybridization with the artificial ハントカジノ 出金時間s serinol ハントカジノ 出金時間 (SNA) or L-threoninol ハントカジノ 出金時間 (L-aTNA), two of the few xeno ハントカジノ 出金時間s capable of binding and forming duplexes with natural RNA effectively. This study was the outcome of collaboration among researchers at the Graduate School of Engineering of Nagoya University, the Graduate School of Pharmaceutical Sciences of Nagoya City University, the Exploratory Research Center on Life and Living Systems (ExCELLS) of the National Institutes of Natural Sciences, and the Graduate School of Engineering of Osaka University.
Natural ハントカジノ 出金時間s like DNA and RNA have a sugar-phosphate "backbone" and nitrogen-based components; while the nitrogen-based components in SNA and L-aTNA remain the same, they have an amino acid-based backbone instead. SNA and L-aTNA have advantages over other artificial ハントカジノ 出金時間s because of their simple structure, easy synthesis, excellent water solubility, and high nuclease resistance. These characteristics make them more suitable for developing ハントカジノ 出金時間 drugs. "Since SNA and L-aTNA can bind to natural ハントカジノ 出金時間s, we wanted to know what the key to stabilize the duplex structure between SNA or L-aTNA and RNA," states Dr. Yukiko Kamiya, the lead scientist on the study, "and therefore, we started to work on determining the three-dimensional structure."
They found that intra-molecular (within-molecule) interactions are important for keeping ハントカジノ 出金時間elical (twisted) double-stranded structures formed of acyclic nucleic acids and RNA stable. While helical structures of natural nucleic acids are A-type, meaning that they twist towards the right, these synthetic duplex structures seemed to align in a perpendicular pattern, resulting in larger areas between each turn of ハントカジノ 出金時間elix. In addition, they obtained triple-stranded structures consisting of L-aTNA or SNA and RNA, through "Hoogsteen base pair" interactions, as shown in Figure 1.
These findings question a lot of things we have so far believed to be fundamental in biology. Ribose, the sugar in the backbone of natural nucleic acids, doesn't seem to be necessary for forming a stable duplex, contrary to the currently accepted knowledge. Then why did nature select ribose? "This is perhaps better answered through future studies looking at ハントカジノ 出金時間elical structure," says Dr. Kamiya.
For now, her team is happy that their findings open up more drug development avenues. "The structural understanding of these duplexes can help us come up with novel designs of ハントカジノ 出金時間-based drugs. We hope that through these findings, the development of ハントカジノ 出金時間 drugs will accelerate," she says.
These insights, of course, go beyond medical applications. ハントカジノ 出金時間s are the blueprints of the "construction" of all living organisms, but we realize that many of their secrets are still uncovered. These findings shed light on a small but significant chapter of ハントカジノ 出金時間s.
As medical research progresses, traditional treatment protocols are being rapidly exhausted. New approaches to treat diseases that do not respond to conventional drugs are the need of ハントカジノ 出金時間our. In search for these approaches, science has turned to a wide range of potential answers, including artificial nucleic acids. Artificial or xeno nucleic acids are similar to naturally occurring nucleic acids (think DNA and RNA) -- but are produced entirely in the laboratory.
Xeno ハントカジノ 出金時間s are essential for the development of ハントカジノ 出金時間-based drugs. To be effective, they need to be able to stably bind to natural RNA (a cellular single-stranded version of the DNA, which is essential for all body processes). However, it is unclear how, if at all, RNA hybridizes with these xeno ハントカジノ 出金時間s. A new study by researchers from Japan sheds light on this mechanism, opening doors to the development of potentially revolutionary ハントカジノ 出金時間-based drugs.
In their experimental study published in Communications Chemistry, the team of the researchers was able to determine three-dimensional structures of RNA hybridization with the artificial ハントカジノ 出金時間s serinol ハントカジノ 出金時間 (SNA) or L-threoninol ハントカジノ 出金時間 (L-aTNA), two of the few xeno ハントカジノ 出金時間s capable of binding and forming duplexes with natural RNA effectively. This study was the outcome of collaboration among researchers at the Graduate School of Engineering of Nagoya University, the Graduate School of Pharmaceutical Sciences of Nagoya City University, the Exploratory Research Center on Life and Living Systems (ExCELLS) of the National Institutes of Natural Sciences, and the Graduate School of Engineering of Osaka University.
Natural ハントカジノ 出金時間s like DNA and RNA have a sugar-phosphate "backbone" and nitrogen-based components; while the nitrogen-based components in SNA and L-aTNA remain the same, they have an amino acid-based backbone instead. SNA and L-aTNA have advantages over other artificial ハントカジノ 出金時間s because of their simple structure, easy synthesis, excellent water solubility, and high nuclease resistance. These characteristics make them more suitable for developing ハントカジノ 出金時間 drugs. "Since SNA and L-aTNA can bind to natural ハントカジノ 出金時間s, we wanted to know what the key to stabilize the duplex structure between SNA or L-aTNA and RNA," states Dr. Yukiko Kamiya, the lead scientist on the study, "and therefore, we started to work on determining the three-dimensional structure."
They found that intra-molecular (within-molecule) interactions are important for keeping ハントカジノ 出金時間elical (twisted) double-stranded structures formed of acyclic nucleic acids and RNA stable. While helical structures of natural nucleic acids are A-type, meaning that they twist towards the right, these synthetic duplex structures seemed to align in a perpendicular pattern, resulting in larger areas between each turn of ハントカジノ 出金時間elix. In addition, they obtained triple-stranded structures consisting of L-aTNA or SNA and RNA, through "Hoogsteen base pair" interactions, as shown in Figure 1.
These findings question a lot of things we have so far believed to be fundamental in biology. Ribose, the sugar in the backbone of natural nucleic acids, doesn't seem to be necessary for forming a stable duplex, contrary to the currently accepted knowledge. Then why did nature select ribose? "This is perhaps better answered through future studies looking at ハントカジノ 出金時間elical structure," says Dr. Kamiya.
For now, her team is happy that their findings open up more drug development avenues. "The structural understanding of these duplexes can help us come up with novel designs of ハントカジノ 出金時間-based drugs. We hope that through these findings, the development of ハントカジノ 出金時間 drugs will accelerate," she says.
These insights, of course, go beyond medical applications. ハントカジノ 出金時間s are the blueprints of the "construction" of all living organisms, but we realize that many of their secrets are still uncovered. These findings shed light on a small but significant chapter of ハントカジノ 出金時間s.
Figure 1
SNA and L-aTNA, comprising a serinol and L-threoninol backbone, respectively, can hybridize with RNA. This study determined the crystal structures of dimers of hetero duplex of L-aTNA/RNA and SNA/RNA stabilized by Hoogsteen base pairs. (Credit: Yukiko Kamiya)
The article
"Intrastrand backbone-nucleobase interactions stabilize unwound right-handed helical structures of heteroduplexes of L-aTNA/RNA and SNA/RNA," was published in the journal Communications Chemistry on November 6, 2020, at DOI: 10.1038/s42004-020-00400-2.
https://www.nature.com/articles/s42004-020-00400-2
https://www.nature.com/articles/s42004-020-00400-2
Media contact
Dr. Yukiko Kamiya Graduate School of Engineering, Nagoya University
Email
yukikok@chembio.nagoya-u.ac.jp
| Title | ハントカジノ 出金時間elix of life: New study shows how "our" RNA stably binds to artificial nucleic acids |
| Author | Yukiko Kamiya,Tadashi Satoh,Atsuji Kodama,Tatsuya Suzuki,Keiji Murayama,Hiromu Kashida,Susumu Uchiyama,Koichi Kato & Hiroyuki Asanuma |