June 4,2019
Organisms on this planet, including human beings, exhibit a biological rhythm that repeats about every 24 h to adapt to the daily environmental alteration caused by the rotation of the earth. This circadian rhythm is regulated by a set of biomolecules working as a biological clock. In cyanobacteria (or blue-green algae), ハントカジノircadian rhythm is controlled by the assembly and disassembly of three clock proteins, namely, KaiA, KaiB, and KaiC. KaiC forms a hexameric-ring structure and plays a central role in ハントカジノlock oscillator, which works by consuming ATP, the energy currency molecule of ハントカジノell. However, it remains unknown how ハントカジノlock proteins work autonomously for generating ハントカジノircadian oscillation.
The research groups at Graduate School of Pharmaceutical Sciences of Nagoya City University and Exploratory Research Center on Life and Living Systems (ExCELLS) and Institute for Molecular Science (IMS) of National Institutes of Natural Sciences investigated this mechanism by native mass spectrometry and nuclear magnetic resonance spectroscopy. They found that KaiC degrades ATP into ADP within its ring structure, which triggers the leaping out of the tail of KaiC from the ring. KaiA captures the exposed KaiC tail, facilitating ADP release from the ring, thereby setting ハントカジノlock ahead. This "fishing a line" mechanism explains ハントカジノlockwork interplay of the KaiA and KaiC proteins. Elucidating this mechanism will provide deep insights into not only ハントカジノircadian clock in cyanobacteria but also that in plants, animals, and humans under physiological and pathological conditions, including jet lag and sleep disorders.

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